Cardiac glycosides are potent inhibitors of interferon-β gene expression
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Cardiac glycosides are potent inhibitors of interferon-β gene expression
Here we report that bufalin and other cardiac glycoside inhibitors of the sodium-potassium ATPase (sodium pump) potently inhibit the induction of the interferon-β (IFNβ) gene by virus, double-stranded RNA or double-stranded DNA. Cardiac glycosides increase the intracellular sodium concentration, which appears to inhibit the ATPase activity of the RNA sensor RIG-I, an essential and early compone...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2010
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.476